Genetic scissors and blood tests: A new model for lung cancer research

Small-cell lung cancer is one of the most aggressive forms of cancer. Tissue samples are rare, making realistic mouse models indispensable. Researchers led by Thorsten Stiewe at Philipps University of Marburg have developed a model in which CRISPR gene-editing technology switches off individual genes directly in the lung, thereby generating tumours. A fluorescent signal in the blood makes them detectable: just a few drops are enough to track their growth – month after month, without the burden of anaesthesia. Gene by gene, it becomes clear which natural brakes must fail and where new therapies can be targeted. The Wilhelm Sander Foundation funded the project with €154,280.